منابع مشابه
The sour taste of a proton current.
S our taste can be agreeable in moderation. However, most people respond to drinking lemon juice with a violent contortion of their faces that clearly signals to everybody around that a mouth free of acid is greatly preferred. Such a strong aversive response must be based on a reliable aciddetection system on the tongue. Emily Liman’s Laboratory of Sensory Neurobiology at the University of Sout...
متن کاملThe K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction.
Sour taste is detected by a subset of taste cells on the tongue and palate epithelium that respond to acids with trains of action potentials. Entry of protons through a Zn(2+)-sensitive proton conductance that is specific to sour taste cells has been shown to be the initial event in sour taste transduction. Whether this conductance acts in concert with other channels sensitive to changes in int...
متن کاملSour taste finds closure in a potassium channel.
Taste cells in taste buds of the mammalian tongue and oral cavity can detect five basic modalities: sweet, bitter, umami, salty, and sour. Each taste cell expresses distinct molecular sensors, such as G protein-coupled receptors or ion channels, which detect tastants (i.e., chemical stimuli that elicit taste sensation) and initiate an intracellular response that culminates in membrane depolariz...
متن کاملOtopetrin 1 activation by purinergic nucleotides regulates intracellular calcium.
Otopetrin1 (Otop1) is a multitransmembrane domain protein required for the formation of otoconia in the vertebrate inner ear. Otoconia are complex calcium carbonate (CaCO(3)) biominerals that are required for the sensation of gravity. Examination of the phenotypes of animals with mutations or deficiencies in Otop1 suggests a direct role for Otop1 in the initiation of extracellular biomineraliza...
متن کاملNeuroscientist Long - Jun Wu 1 in MicrogliaVVoltage - Gated Proton Channel
Microglia are brain resident immune cells and their functions are implicated in both the normal and diseased brain. Microglia express a plethora of ion channels, including K channels, Na channels, TRP channels, Cl channels, and proton channels. These ion channels play critical roles in microglial proliferation, migration, and production/release of cytokines, chemokines, and neurotoxic or neurot...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2018
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.201812003